METHODS: Coating prescription was optimized by uniform design and the cumulative rates of drug release of different formulated preparations were measured, pharmaceutical features of domiphen bromide osmotic tablet and mechanism of drug release were studied. 方法:以均匀设计法优化包衣工艺,测定不同处方制剂累积释药百分率,研究渗透泵片的制剂学特征及释药机制。
In the studies of synthesis of domiphen bromide, the chemical kinetic method was used. 在度米芬合成研究时,采用了化学动力学方法。